Endocrine Abstracts

Background: Polycystic ovarian syndrome (PCOS) is a common reproductive-endocrine disorder seen in women; characterized by increased GnRH pulsatility, hyperandrogenism, and cyst formation in ovary. GnRH release is controlled by higher centres of brain namely, hypothalamus and pituitary through various feedback mechanisms, one of them being neurotransmitters. However, no clear data is available with respect to GnRH regulation by neurotransmitters in PCOS. The aim of the present...

Background and aim: polycystic ovarian syndrome is a multi aetiological female endocrinopathy wherein one of the major target organs affected is adrenal. It is important to note that adrenal plays key role in evoking stress mediated responses in brain; which can in turn affect GnRH, the main regulator of HPG axis. Along with corticotrophin releasing factor (CRF), newly discovered neuropeptides- urocortin2 and RF-amide related peptide-3 (RFRP-3) (mammalian GnIH analogue) are al...